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[SAGA complex: the role in viability and development].

作者信息

Gurskiĭ D Ia, Kopytova D V, Georgieva S G, Nabirochkina E N

出版信息

Mol Biol (Mosk). 2013 Nov-Dec;47(6):922-6.

Abstract

SAGA is a histone acetyltransferase complex, that cotranscriptionally performs histone modifications and is implicated in regulation of gene expression at the level of changes in chromatin structure. SAGA is also involved in mRNP biogenesis and export. In this review, we examined a contribution of SAGA and its subunits in the development. We also discuss the diseases associated with impaired activity of SAGA subunits.

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