Manolov V, Marinov B, Masseva A, Vasilev V
Akush Ginekol (Sofiia). 2014;53 Suppl 2:15-8.
Preeclampsia is a multifactorial disease characterized by hypertension and proteinuria after 20 weeks of gestation of the pregnancy. Preeclampsia is characterized by the deposition of fibrin in the walls of small blood vessels. D-dimer was used as a marker for degradation/synthesis of fibrin in vivo. D-dimer has emerged as a useful indicator in the diagnosis of thrombotic conditions because its plasma concentration has a high predictive value for the assessment of venous thromboembolism. The purpose of this study was to evaluate plasma levels of D-dimer and preeclampsia compared to normal pregnancy occurs. We found that elevated levels of D-dimer is associated with the development of preeclampsia in the third trimester of pregnancy compared with normal pregnancy occurs. Preliminary findings highlight the need for further in-depth studies during pregnancy in order to fully clarify the diagnostic/prognostic role of D-dimer preeclampsia.
子痫前期是一种多因素疾病,其特征为妊娠20周后出现高血压和蛋白尿。子痫前期的特点是小血管壁中有纤维蛋白沉积。D-二聚体被用作体内纤维蛋白降解/合成的标志物。由于其血浆浓度对静脉血栓栓塞的评估具有较高的预测价值,D-二聚体已成为诊断血栓形成疾病的有用指标。本研究的目的是评估与正常妊娠相比,子痫前期患者的血浆D-二聚体水平。我们发现,与正常妊娠相比,妊娠晚期子痫前期的发生与D-二聚体水平升高有关。初步研究结果强调,孕期需要进一步深入研究,以充分阐明D-二聚体在子痫前期诊断/预后中的作用。