Nolan T E, Smith R P, Devoe L D
Department of Obstetrics and Gynecology, Medical College of Georgia, Augusta.
Obstet Gynecol. 1993 Feb;81(2):235-8.
To evaluate D-dimer as a marker for fibrinolysis in normal and complicated pregnancies using an enzyme-linked immunosorbent assay (ELISA) technique.
Four groups of pregnant women were enrolled: 17 normal women followed longitudinally from 28-40 weeks' gestation, 14 patients with preterm labor at 28-34 weeks, 17 patients with preeclampsia at term (37-40 weeks), and 14 patients with abruptio placentae (32-40 weeks). We assayed peripheral venous blood samples from each patient for D-dimer levels using a commercial ELISA kit. D-dimer values were calculated by regression analysis using internal standards and controls for each assay. Data were compared using Student t test or analysis of variance with repeated measures.
D-dimer values increased slightly with increasing gestational age. Patients with preterm labor, preeclampsia, and abruptio placentae had mean D-dimer values significantly greater than those of controls (P < .003). D-dimer values of the abruption group were approximately twice those of the control group (3393 +/- 2086 versus 1750 +/- 839 ng/dL).
An increase in fibrinolysis may be associated with the pregnancy complications studied, as reflected by alterations in maternal plasma D-dimer levels.
采用酶联免疫吸附测定（ELISA）技术评估D - 二聚体作为正常妊娠和并发妊娠中纤维蛋白溶解标志物的作用。
纳入四组孕妇：17名从妊娠28至40周纵向随访的正常孕妇，14名妊娠28至34周早产的患者，17名足月（37至40周）子痫前期的患者，以及14名胎盘早剥（32至40周）的患者。我们使用商用ELISA试剂盒检测每位患者外周静脉血样本中的D - 二聚体水平。D - 二聚体值通过使用每次检测的内标和对照进行回归分析来计算。数据使用Student t检验或重复测量方差分析进行比较。
D - 二聚体值随孕周增加略有升高。早产、子痫前期和胎盘早剥患者的平均D - 二聚体值显著高于对照组（P <.003）。胎盘早剥组的D - 二聚体值约为对照组的两倍（3393 ± 2086对1750 ± 839 ng/dL）。
如母体血浆D - 二聚体水平的变化所反映，纤维蛋白溶解增加可能与所研究的妊娠并发症有关。
