Sahasrabuddhe Anagh A, Elenitoba-Johnson Kojo S J
Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
Immunol Rev. 2015 Jan;263(1):224-39. doi: 10.1111/imr.12236.
Ubiquitination is a post-translational modification process that regulates several critical cellular processes. Ubiquitination is orchestrated by the ubiquitin proteasome system (UPS), which constitutes a cascade of enzymes that transfer ubiquitin onto protein substrates. The UPS catalyzes the destruction of many critical protein substrates involved in cancer pathogenesis. This review article focuses on components of the UPS that have been demonstrated to be deregulated by a variety of mechanisms in hematologic malignancies. These include E3 ubiquitin ligases and deubiquitinating enzymes. The prospects of specific targeting of key enzymes in this pathway that are critical to the pathogenesis of particular hematologic neoplasia are also discussed.
泛素化是一种翻译后修饰过程，可调节多种关键的细胞过程。泛素化由泛素蛋白酶体系统（UPS）精心调控，该系统由一系列将泛素转移到蛋白质底物上的酶组成。UPS催化许多参与癌症发病机制的关键蛋白质底物的降解。这篇综述文章聚焦于UPS的组成部分，这些组成部分已被证明在血液系统恶性肿瘤中通过多种机制失调。其中包括E3泛素连接酶和去泛素化酶。本文还讨论了特异性靶向该途径中对特定血液系统肿瘤发病机制至关重要的关键酶的前景。
