Hansen O R, Nøkkentved K
Ugeskr Laeger. 1989 Aug 28;151(35):2194-5.
During a period of ten years, 13 children were treated for infantile spasms with ACTH. Eleven of these developed Cushing-like appearance, 9 irritability, 7 hypokalaemia, 6 metabolic alkalosis, 5 hypertension, 5 infections and 5 osteoporosis. This investigation reveals that osteoporosis is a more frequent side effect than previously recognized and, similarly, that hypertension is also a common side effect. Routine x-ray control of the thoracic spine, regular measurement of blood pressure and control of urinary calcium and serum calcium, phosphate, sodium and potassium are therefore recommended. As cases of ureteronephrolithiasis have also been observed, examination of the urine for blood and ultrasound examination of the kidneys for formation of calculi should also be considered.
在十年期间，13名儿童接受了促肾上腺皮质激素（ACTH）治疗婴儿痉挛症。其中11名出现了库欣样外貌，9名出现易激惹，7名出现低钾血症，6名出现代谢性碱中毒，5名出现高血压，5名出现感染，5名出现骨质疏松症。这项调查显示，骨质疏松症是一种比之前认识到的更为常见的副作用，同样，高血压也是一种常见的副作用。因此，建议对胸椎进行常规X线检查，定期测量血压，并监测尿钙和血清钙、磷、钠及钾。由于也观察到了输尿管肾结石病例，因此还应考虑检查尿液中的血液，并对肾脏进行超声检查以查看结石形成情况。
