S100A4表达与胃癌预后：一项荟萃分析

S100A4 expression and prognosis of gastric cancer: a meta-analysis.

作者信息

Wang Y, Zhou L-B, Li X-H

机构信息

Department of General Surgery, Second Affiliated Hospital of Anhui Medical University, Hefei, China.

Department of Digestive Medicine, Shanghai Eighth People's Hospital, Shanghai, China

出版信息

Genet Mol Res. 2014 Dec 12;13(4):10398-403. doi: 10.4238/2014.December.12.1.

DOI:10.4238/2014.December.12.1

PMID:25511023

Abstract

The prognostic role of S100A4 in gastric cancer is still under debate. The present meta-analysis aimed to evaluate the relationship between S10A4 levels and the prognosis of gastric cancer. We performed a meta-analysis of published studies assessing the relationship between S100A4 and gastric cancer prognosis. We used the Revman 5.0 software to perform literature retrieval, article selection, data collection, and statistical analysis. A fixed-effect model was used to pool the hazard ratio (HR) and 95% confidence intervals (95%CI). A total of 7 eligible studies that included 1257 gastric cancer patients were analyzed. We did not find a prognostic value for S100A4 in gastric cancer (HR = 1.48, 95%CI = 0.77 to 2.82, P = 0.24). In conclusion, the present study indicated that S100A4 expression level is not a prognostic factor for gastric cancer.

摘要

S100A4在胃癌中的预后作用仍存在争议。本荟萃分析旨在评估S10A4水平与胃癌预后之间的关系。我们对已发表的评估S100A4与胃癌预后关系的研究进行了荟萃分析。我们使用Revman 5.0软件进行文献检索、文章筛选、数据收集和统计分析。采用固定效应模型汇总风险比（HR）和95%置信区间（95%CI）。共分析了7项符合条件的研究，纳入1257例胃癌患者。我们未发现S100A4在胃癌中有预后价值（HR = 1.48，95%CI = 0.77至2.82，P = 0.24）。总之，本研究表明S100A4表达水平不是胃癌的预后因素。