C-erbB-2表达与胃癌预后：一项荟萃分析。

C-erbB-2 expression and prognosis of gastric cancer: a meta-analysis.

作者信息

Wang Z Q, Sun B J

机构信息

Department of Surgery, Affiliated Tongren Hospital, Shanghai Jiaotong University, Shanghai, China.

Department of Surgery, Affiliated Tongren Hospital, Shanghai Jiaotong University, Shanghai, China

出版信息

Genet Mol Res. 2015 Mar 13;14(1):1782-7. doi: 10.4238/2015.March.13.5.

DOI:10.4238/2015.March.13.5

PMID:25867322

Abstract

The prognostic role of c-erbB-2 in gastric cancer is controversial. We conducted a meta-analysis to evaluate the relationship between c-erbB-2 expression and the prognosis of gastric cancer. We evaluated 20 published studies assessing the relationship between c-erbB-2 and gastric cancer prognosis. The Revman 5.0 software was used to perform literature retrieval, article selection, data collection, and statistical analysis. We utilized a fixed-effect model to pool hazard ratios and 95% confidence intervals from the studies. A total of 20 eligible studies including 4468 gastric cancer patients were analyzed. We were unable to demonstrate the prognostic value of c-erbB-2 for gastric cancer (hazard ratio = 1.01, 95% confidence interval = 0.87-1.16, P = 0.93). The present study indicated that c-erbB-2 expression is not a prognostic factor for gastric cancer.

摘要

c-erbB-2在胃癌中的预后作用存在争议。我们进行了一项荟萃分析，以评估c-erbB-2表达与胃癌预后之间的关系。我们评估了20项已发表的研究，这些研究评估了c-erbB-2与胃癌预后之间的关系。使用Revman 5.0软件进行文献检索、文章筛选、数据收集和统计分析。我们采用固定效应模型汇总各研究中的风险比和95%置信区间。共分析了20项符合条件的研究，包括4468例胃癌患者。我们无法证明c-erbB-2对胃癌的预后价值（风险比=1.01，95%置信区间=0.87-1.16，P=0.93）。本研究表明，c-erbB-2表达不是胃癌的预后因素。