Assessment of mean platelet volume (MPV) in primary hyperparathyroidism: effects of successful parathyroidectomy on MPV levels.

OBJECTIVE

A determinant of platelet function - mean platelet volume (MPV), is newly emerging risk factor for atherothrombosis. The aim of this study is to evaluate MPV in patients with primary hyperparathyroidism (PHPT) before parathyroidectomy (PTX) and six months after successful PTX in a retrospective study.

METHODS

We analyzed the changes in serum biochemical, parathyroid hormone (PTH) and MPV before and six months after PTX in 66 patients with PHPT and 44 healthy controls, age- and sex-matched.

RESULTS

Sixty-six patients (18 men, 48 women) with mean age 53.8 ± 12.7 years were analyzed. MPV was significantly higher in the patients with PHPT before PTX than in the same group after PTX (9.26 ± 1.20 fl vs. 7.99 ± 0.80 fl, p<0.0001). MPV levels were positively correlated with PTH (r=0.888, p<0.0001), calcium (r=0.292, p=0.017) in the preoperative phase. Postoperative (after 6 months) MPV showed a significant positive correlation with postoperative PTH (r=0.381, p=0.002) and calcium levels (r=0.324, p=0.008).

CONCLUSIONS

These results suggest that subjects with PHPT lead to have increased platelet activation.