Boldyrev A A, Lopina O D, Svinukhova I A
Biokhimiia. 1989 Jun;54(6):895-908.
The mechanism of Na,K-ATPase function is reviewed. The peculiarities of hydrolysis of various substrates are described. The experimental results testify to the effect of substrate structure on the E2----E1 transition, rate of Na+ transport, K-dependent phosphatase activation and the quaternary structure of Na,K-ATPase. A conclusion is drawn that the proton-acceptor properties of the substrate play a role in the regulation of ion transport by Na,K-ATPase.
本文综述了钠钾ATP酶的作用机制。描述了各种底物水解的特性。实验结果证实了底物结构对E2→E1转变、钠离子转运速率、钾离子依赖性磷酸酶激活以及钠钾ATP酶四级结构的影响。得出的结论是，底物的质子受体特性在钠钾ATP酶对离子转运的调节中起作用。
