Karanti Alina, Kardell Mathias, Lundberg Ulrika, Landén Mikael
Institutionen för neurovetenskap och fysiologi, Göteborgs universitet - Sektionen för psykiatri och neurokemi Göteborg, Sweden Neuroscience and Physiology - Psychiatry and Neurochemistry, University of Gothenburg Gothenburg, Sweden.
BipoläR- Nationella kvalitetsregistret för bipolär affektiv sjukdom - Göteborgs universitet Göteborg, Sweden National Quality Register for bipolar disorder BipoläR - University of Gothenburg Gothenburg, Sweden.
Lakartidningen. 2014 Dec 16;111(51-52):2284-6.
Lithium is a first line option in the maintenance treatment of bipolar disorder, but several alternative treatment regimens have been introduced in recent years, among them treatment with antiepileptic compounds and atypical antipsychotic drugs. Little is known about if and how this has changed the prescription patterns of mood stabilizers. We analysed trends in prescription of mood stabilisers in Sweden using the national quality register for bipolar disorder (BipoläR), the Prescribed Drug Register, and the Patient Register during the years 2007-2011. We found that lithium use decreased while lamotrigine use increased in bipolar patients. These changes could not be ex-plained by differences in bipolar subtypes; lithium use decreased in both bipolar type I and type II, and the use of lamotrigine increased in bipolar type II. Lithium use was more common in men, whereas lamotrigine use was more common in women. The prescription of other mood stabilisers did not change during these years.
锂盐是双相情感障碍维持治疗的一线选择，但近年来已引入了几种替代治疗方案，其中包括使用抗癫痫化合物和非典型抗精神病药物进行治疗。关于这是否以及如何改变了心境稳定剂的处方模式，人们知之甚少。我们利用瑞典双相情感障碍国家质量登记册（BipoläR）、处方药登记册和患者登记册，分析了2007年至2011年期间瑞典心境稳定剂的处方趋势。我们发现，双相情感障碍患者中锂盐的使用减少，而拉莫三嗪的使用增加。这些变化无法用双相情感障碍亚型的差异来解释；双相I型和II型患者中锂盐的使用均减少，而双相II型患者中拉莫三嗪的使用增加。锂盐的使用在男性中更为常见，而拉莫三嗪的使用在女性中更为常见。这些年里其他心境稳定剂的处方没有变化。
