J Agric Food Chem. 2015 Jan 14;63(1):200-7. doi: 10.1021/jf504289g.
Three new phenolic compounds, coretinphenol (1), coretincone (2), and coretinphencone (3), were isolated from the buds of Coreopsis tinctoria Nutt., together with nine known compounds, including butein (4), okanin (5), isoliquiritigenin (6), maritimetin (7), taxifolin (8), isookanin (9), marein (10), sachalinoside B (11), and 2-phenylethyl-β-d-glucoside (12). The chemical structures of these compounds were elucidated by extensive spectroscopic analysis and on the basis of their chemical reactivity. This work represents the first recorded example of the isolation of compounds 1–3, 6, 7, 9, 11, and 12 from C. tinctoria. Compounds 5–9 showed strong diphenyl(2,4,6-trinitrophenyl)iminoazanium (DPPH) radical-scavenging activity, with IC50 values of 3.35 ± 0.45, 9.6 ± 2.32, 4.12 ± 0.21, 6.2 ± 0.43, and 7.9 ± 0.53 μM, respectively. Compounds 2 and 8 exhibited angiotensin I-converting enzyme inhibitory activity, with IC50 values of 228 ± 4.47 and 145.67 ± 3.45 μM, respectively. The activities of phenolic compounds isolated from C. tinctoria support the medicinal use of this plant in the prevention of cardiovascular diseases.
从金鸡菊的芽中分离得到了三种新的酚类化合物，分别为考替酚（1）、考替酮（2）和考替苯醌（3），此外还分离得到了 9 种已知化合物，包括布替醇（4）、奥卡宁（5）、异甘草素（6）、马里替汀（7）、杨梅素（8）、异奥卡宁（9）、马雷因（10）、沙蟾苷 B（11）和 2-苯乙基-β-d-葡萄糖苷（12）。通过广泛的光谱分析和基于其化学反应性，确定了这些化合物的化学结构。这是首次从金鸡菊中分离得到化合物 1-3、6、7、9、11 和 12。化合物 5-9 对二苯基（2,4,6-三硝基苯基）亚氨基自由基（DPPH）具有很强的清除活性，IC50 值分别为 3.35±0.45、9.6±2.32、4.12±0.21、6.2±0.43 和 7.9±0.53 μM。化合物 2 和 8 对血管紧张素 I 转化酶具有抑制活性，IC50 值分别为 228±4.47 和 145.67±3.45 μM。从金鸡菊中分离得到的酚类化合物具有活性，支持了该植物在预防心血管疾病方面的药用价值。
