Mori Yasuhisa, Sato Norihiro, Matayoshi Nobutaka, Tamura Toshihisa, Minagawa Noritaka, Shibao Kazunori, Higure Aiichiro, Nakamoto Mitsuhiro, Taguchi Masashi, Yamaguchi Koji
Yasuhisa Mori, Norihiro Sato, Nobutaka Matayoshi, Toshihisa Tamura, Noritaka Minagawa, Kazunori Shibao, Aiichiro Higure, Koji Yamaguchi, Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Fukuoka 807-8555, Japan.
World J Gastroenterol. 2014 Dec 14;20(46):17661-5. doi: 10.3748/wjg.v20.i46.17661.
Familial adenomatous polyposis is associated with a high incidence of malignancies in the upper gastrointestinal tract (particularly ampullary adenocarcinomas). However, few reports have described a correlation between familial adenomatous polyposis and gallbladder neoplasms. We present a case of a 60-year-old woman with familial adenomatous polyposis who presented with an elevated mass in the neck of the gallbladder (measuring 16 mm × 8 mm in diameter) and multiple small cholecystic polyps. She had undergone a total colectomy for ascending colon cancer associated with familial adenomatous polyposis 22 years previously. The patient underwent laparoscopic cholecystectomy under a preoperative diagnosis of multifocal gallbladder polyps. Pathologic examination of the resected gallbladder revealed more than 70 adenomatous lesions, a feature consistent with adenoma of the gallbladder. This case suggests a requirement for long-term surveillance of the biliary system in addition to the gastrointestinal tract in patients with familial adenomatous polyposis.
家族性腺瘤性息肉病与上消化道恶性肿瘤(尤其是壶腹腺癌)的高发病率相关。然而,很少有报告描述家族性腺瘤性息肉病与胆囊肿瘤之间的相关性。我们报告一例60岁患有家族性腺瘤性息肉病的女性,其胆囊颈部有一隆起性肿物(直径16 mm×8 mm)以及多个小的胆囊息肉。22年前她因与家族性腺瘤性息肉病相关的升结肠癌接受了全结肠切除术。该患者在术前诊断为多灶性胆囊息肉的情况下接受了腹腔镜胆囊切除术。切除胆囊的病理检查发现70多个腺瘤性病变,这一特征符合胆囊腺瘤。该病例提示,对于家族性腺瘤性息肉病患者,除了对胃肠道进行长期监测外,还需要对胆道系统进行长期监测。