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Expert Rev Anticancer Ther. 2013 Jun;13(6):745-58. doi: 10.1586/era.13.47.
2
The T393C polymorphism of GNAS1 as a predictor for chemotherapy sensitivity and survival in advanced non-small-cell lung cancer patients treated with gemcitabine plus platinum.GNAS1 基因 T393C 多态性可预测吉西他滨联合铂类化疗治疗晚期非小细胞肺癌患者的敏感性和生存。
Cancer Chemother Pharmacol. 2012 Jun;69(6):1443-8. doi: 10.1007/s00280-012-1849-3. Epub 2012 Feb 28.
3
The GNAS1 T393C single nucleotide polymorphism predicts the natural postoperative course of complete resected esophageal cancer.GNAS1 T393C 单核苷酸多态性预测完全切除的食管癌的自然术后过程。
Cell Oncol (Dordr). 2011 Aug;34(4):281-8. doi: 10.1007/s13402-011-0016-x. Epub 2011 Feb 22.
4
Global cancer statistics.全球癌症统计数据。
CA Cancer J Clin. 2011 Mar-Apr;61(2):69-90. doi: 10.3322/caac.20107. Epub 2011 Feb 4.
5
GNAS1 T393C polymorphism and disease progression in patients with malignant melanoma.GNAS1 T393C 多态性与恶性黑色素瘤患者的疾病进展。
Eur J Med Res. 2010 Oct 25;15(10):422-7. doi: 10.1186/2047-783x-15-10-422.
6
Association of the GNAS1 T393C polymorphism with tumor stage and survival in gastric cancer.GNAS1 T393C 多态性与胃癌的肿瘤分期和生存的关联。
World J Gastroenterol. 2009 Dec 28;15(48):6061-7. doi: 10.3748/wjg.15.6061.
7
The GNAS1 T393C polymorphism predicts survival in patients with advanced squamous cell carcinoma of the larynx.GNAS1基因T393C多态性可预测晚期喉鳞状细胞癌患者的生存率。
Laryngoscope. 2008 Dec;118(12):2172-6. doi: 10.1097/MLG.0b013e318185793ds.
8
Non-small cell lung cancer: epidemiology, risk factors, treatment, and survivorship.非小细胞肺癌：流行病学、危险因素、治疗及生存情况。
Mayo Clin Proc. 2008 May;83(5):584-94. doi: 10.4065/83.5.584.
9
Overall and relapse-free survival in oropharyngeal and hypopharyngeal squamous cell carcinoma are associated with genotypes of T393C polymorphism of the GNAS1 gene.口咽和下咽鳞状细胞癌的总生存率和无复发生存率与GNAS1基因T393C多态性的基因型相关。
Clin Cancer Res. 2008 Mar 15;14(6):1753-8. doi: 10.1158/1078-0432.CCR-07-1605.
10
The GNAS1 T393C polymorphism and lack of clinical prognostic value in chronic lymphocytic leukemia.GNAS1基因T393C多态性与慢性淋巴细胞白血病临床预后价值的缺失
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GNAS1基因T393C多态性的TT基因型预示晚期非小细胞肺癌患者有更好的预后。

TT genotype of GNAS1 T393C polymorphism predicts better outcome of advanced non-small cell lung cancer patients.

作者信息

Gong Hong-Yun, Hu Wei-Guo, Wang Xiu-Ling, Zhu Fan, Song Qin-Bin

机构信息

Hong-Yun Gong, Wei-Guo Hu, Qin-Bin Song, Department of Oncology, Renmin Hospital of Wuhan University, Wuhan 430060, Hebei Province, China.

出版信息

World J Gastrointest Oncol. 2014 Dec 15;6(12):444-9. doi: 10.4251/wjgo.v6.i12.444.

DOI:10.4251/wjgo.v6.i12.444
PMID:25516778
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4266817/
Abstract

AIM

To evaluate the potential prognostic value of GNAS1 T393C polymorphism in advanced non-small cell lung cancer.

METHODS

We extracted genomic DNA from the peripheral blood leucocytes of 94 patients with advanced non-small cell lung cancer. Quantitative real-time polymerase chain reaction was used to determine the allelic discrimination. The correlation between genotype and overall survival was evaluated using the multivariate analysis and Kaplan-Meier approach.

RESULTS

Thirty-eight out of 94 (40%) patients displayed a TT genotype, 29 out of 94 (31%) a CT genotype and 27 out of 94 (29%) a CC genotype. The median survival of TT (25 mo) genotype carriers was longer than CT (12 mo) or CC (8 mo) genotype carriers. The favorable TT genotype predicted better overall survival (OS) (2-year OS: 48%; P =0.01) compared with CT (2-year OS: 18%) or CC (2-year OS: 15%) genotype. However, dichotomization between C-genotypes (CC + CT) and T-genotypes (TT) revealed significantly lower survival rates (2-year OS: 16%; P = 0.01) for C allele carriers.

CONCLUSION

Our data provided strong evidence that the GNAS1 T393C genetic polymorphism influenced the prognosis in advanced non-small lung cancer with a worse outcome for C allele carriers.

摘要

目的

评估GNAS1基因T393C多态性在晚期非小细胞肺癌中的潜在预后价值。

方法

我们从94例晚期非小细胞肺癌患者的外周血白细胞中提取基因组DNA。采用定量实时聚合酶链反应来确定等位基因鉴别。使用多变量分析和Kaplan-Meier方法评估基因型与总生存期之间的相关性。

结果

94例患者中，38例（40%）表现为TT基因型，29例（31%）为CT基因型，27例（29%）为CC基因型。TT基因型（25个月）携带者的中位生存期长于CT基因型（12个月）或CC基因型（8个月）携带者。与CT基因型（2年总生存率：18%）或CC基因型（2年总生存率：15%）相比，有利的TT基因型预测总生存期（OS）更好（2年总生存率：48%；P =0.01）。然而，C基因型（CC + CT）和T基因型（TT）之间的二分法显示，C等位基因携带者的生存率显著较低（2年总生存率：16%；P =0.01）。

结论

我们的数据提供了有力证据，表明GNAS1基因T393C基因多态性影响晚期非小细胞肺癌的预后，C等位基因携带者的预后较差。