Bendix J M, Hegaard H K, Bergholt T, Langhoff-Roos J
a Department of Gynaecology & Obstetrics , Nordsjaellands Hospital, Hillerod, University of Copenhagen , Denmark.
b The Research Unit Women's and Children's Health, the Juliane Marie Centre, Rigshospitalet, University of Copenhagen , Denmark.
J Obstet Gynaecol. 2015;35(6):570-7. doi: 10.3109/01443615.2014.987114. Epub 2014 Dec 17.
Women with pre-term pre-labour rupture of membranes (PPROM) 22-33 weeks' gestation were included in a retrospective cohort study with a structured audit to identify risk factors of major complications following PPROM and to assess whether these complications are predictable. Of the 234 women analysed, 106 (45%) delivered within three days. Eighty-four women (36%) had at least one major complication and 45% of these complications occurred within three days. The complication rate was 64% in early PPROM before 28 weeks' gestation and 11% in late PPROM at 28 weeks' gestation or later. Nulliparous women had an increased risk of major complications (adjusted hazards ratio: 3.07 (95% confidence interval: 1.28-7.37)). The complication rates were highest in early PPROM and during the first three days after PPROM. Multiparous women with late PPROM, who do not deliver within the first three days, have the lowest risk of major complications and are suitable for home care.
孕周为22 - 33周的胎膜早破（PPROM）女性被纳入一项回顾性队列研究，该研究采用结构化审计来确定PPROM后主要并发症的风险因素，并评估这些并发症是否可预测。在分析的234名女性中，106名（45%）在三天内分娩。84名女性（36%）至少出现一种主要并发症，其中45%的并发症发生在三天内。孕28周前的早期PPROM并发症发生率为64%，孕28周及以后的晚期PPROM并发症发生率为11%。未生育女性发生主要并发症的风险增加（调整后风险比：3.07（95%置信区间：1.28 - 7.37））。并发症发生率在早期PPROM以及PPROM后的头三天最高。晚期PPROM且未在头三天内分娩的经产妇发生主要并发症的风险最低，适合在家护理。
