Hsueh Aaron J W
Department of Gynecology and Obstetrics, Stanford University School of Medicine, Stanford, CA 94305, USA.
Curr Biol. 2014 Nov 3;24(21):R1040-2. doi: 10.1016/j.cub.2014.09.033.
Activation of a limited pool of diminishing ovarian follicles determines women's reproductive lifespan. A recent rodent study describes the role of mTOR signaling and KIT ligand in granulosa cells of primordial follicles for follicle activation and for reproductive lifespan regulation.
有限数量且不断减少的卵巢卵泡的激活决定了女性的生殖寿命。最近一项针对啮齿动物的研究描述了mTOR信号传导和KIT配体在原始卵泡颗粒细胞中对卵泡激活和生殖寿命调节的作用。