干细胞向胰岛素分泌细胞的转化：两步走，现在是暂停的时候了？
Stem cells to insulin secreting cells: two steps forward and now a time to pause?
机构信息
McNair Medical Institute, Pediatric Diabetes and Endocrinology, Baylor College of Medicine, Texas Children's Hospital, Houston, TX 77030, USA.
Department of Pharmacology, University of Alberta, Edmonton, AB T6G 2E1, Canada; Alberta Diabetes Institute, Edmonton, AB T6G 2E1, Canada.
出版信息
Cell Stem Cell. 2014 Nov 6;15(5):535-6. doi: 10.1016/j.stem.2014.10.012.
Two groups recently reported the in vitro differentiation of human embryonic stem cells into insulin-secreting cells, achieving an elusive goal for regenerative medicine. Herein we provide a perspective regarding these developments, compare phenotypes of the insulin-containing cells to human β cells, and discuss implications for type 1 diabetes research and clinical care.
最近有两组研究人员报告称，已成功将人类胚胎干细胞在体外分化为能分泌胰岛素的细胞，这一目标的实现为再生医学带来了新的希望。本文就这一进展进行了讨论，并对这些含胰岛素细胞的表型与人胰岛β细胞进行了比较，同时还探讨了其在 1 型糖尿病研究和临床治疗方面的应用价值。
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