Pereira Alexandre Luiz Albuquerque, Ferreira Márcia Raissa Aragão, Santos Orlando José dos, Sauaia Filho Euler Nicolau, Paiva Antônio Ernandes Macedo, Santos Rayan Haquim Pinheiro, Santos Rennan Abud Pinheiro
Department of Physiotherapy, Faculty Santa Terezinha, Sao Luis, MA, Brazil.
CEST, Sao Luis, MA, Brazil.
Acta Cir Bras. 2014 Dec;29(12):771-5. doi: 10.1590/S0102-86502014001900001.
To analyze microscopically the effects of different concentrations of oxygen in the lungs of rats.
There were 20 rats distributed in three experimental groups (concentration of oxygen to 40%, 70% and 100%) and a control group. The animals were exposed to the oxygen in a chamber of acrylic during three days and after exposition, the animals were submitted to median thoracotomia to remove the lungs. The lung tissue of all of the animals was analyzed as regards presence of acute and chronic inflammation, capillary congestion, alveolar walls thick, interstitial and alveolar edema, alveolar hemorrhage, denudation capillary and alveolar endothelium areas and atelectasis.
The analysis histopathologic revealed significant statistics difference for acute and chronic inflammation, capillary congestion, alveolar walls thick, interstitial and alveolar edema, alveolar hemorrhage, denudation capillary and alveolar epithelium areas.
Exposition to the oxygen during 72 hours in the concentration of 40% does not produce significant histopathologic alterations in the lung tissue; in the concentration of 70%, can promotes the alveolar walls thick and capillary congestion and in the concentration of 100% can cause death and originate diffuse pulmonary lesion.
通过显微镜分析不同浓度氧气对大鼠肺部的影响。
20只大鼠分为三个实验组（氧气浓度分别为40%、70%和100%）和一个对照组。动物在丙烯酸舱内暴露于相应氧气浓度环境中三天，暴露后，对动物进行中位开胸手术以取出肺部。分析所有动物的肺组织，观察急性和慢性炎症、毛细血管充血、肺泡壁增厚、间质和肺泡水肿、肺泡出血、毛细血管和肺泡内皮剥脱面积以及肺不张情况。
组织病理学分析显示，在急性和慢性炎症、毛细血管充血、肺泡壁增厚、间质和肺泡水肿、肺泡出血、毛细血管和肺泡上皮剥脱面积方面存在显著统计学差异。
72小时暴露于40%浓度的氧气不会在肺组织中产生显著的组织病理学改变；70%浓度可促进肺泡壁增厚和毛细血管充血，而100%浓度可导致死亡并引发弥漫性肺部病变。
