Van Zyl J M, Basson K, Van der Walt B J
Department of Pharmacology, University of Stellenbosch, Medical School, Tygerberg, South Africa.
Horm Metab Res. 1989 Aug;21(8):441-4. doi: 10.1055/s-2007-1009257.
Thyroxine and triiodothyronine concentrations of 50 nM or lower can stimulate the chlorinating activity of the myeloperoxidase-H2O2-Cl- antimicrobial system in vitro. The initial rates of the chlorinating reaction with monochlorodimedone were similar for both thyroid hormones. Maximum stimulation occurred around pH 6 and a linear relationship exists between stimulation and thyroxine concentrations up to at least 1 microM. Of the various thyroxine analogues tested, stimulation was in the order: T4 (or T3) greater than triiodothyropropionic acid greater than 3,5-T2. Diiodotyrosine did not have any significant stimulatory effect. The oxidised product of the phenolic ring of T4, presumably a hydroxyquinone, may act as an additional electron carrier and thereby facilitates redox reactions.
在体外，50 nM或更低浓度的甲状腺素和三碘甲状腺原氨酸可刺激髓过氧化物酶-H2O2-Cl-抗菌系统的氯化活性。两种甲状腺激素与一氯二甲基酮发生氯化反应的初始速率相似。最大刺激作用出现在pH 6左右，并且在刺激作用与甲状腺素浓度之间存在线性关系，直至至少1 microM。在所测试的各种甲状腺素类似物中，刺激作用顺序为：T4（或T3）＞三碘甲状腺丙酸＞3,5-T2。二碘酪氨酸没有任何显著的刺激作用。T4酚环的氧化产物，可能是一种羟基醌，可作为额外的电子载体，从而促进氧化还原反应。
