Zaichick Vladimir, Zaichick Sofia, Davydov German
Radionuclide Diagnostics Department, Medical Radiological Research Centre, Koroleva St.-4, Obninsk, 249036, Kaluga Region, Russia,
Biol Trace Elem Res. 2015 Mar;164(1):25-35. doi: 10.1007/s12011-014-0204-4. Epub 2014 Dec 18.
In order to clarify the differences between Ag, Br, Ca, Co, Cr, Fe, Hg, K, Mg, Mn, Na, Rb, Sb, Sc, Se, and Zn contents in hyperplastic (patients with benign prostate hyperplasia (BPH), n = 32) and nonhyperplastic (control group of healthy male inhabitants, n = 32) prostates, an instrumental neutron activation analysis was performed. Mean values (M ± SΕΜ) for mass fraction (mg/kg, dry mass basis) of chemical elements in glands of patients with BPH were the following: Ag, 0.0346 ± 0.0060; Br, 30.4 ± 3.6; Ca, 2030 ± 165; Co, 0.0716 ± 0.0097; Cr, 1.073 ± 0.119; Fe, 130.0 ± 7.9; Hg, 0.232 ± 0.030; K, 14,470 ± 740; Mg, 1200 ± 80; Mn, 1.19 ± 0.09; Na, 11,610 ± 870; Rb, 14.7 ± 0.8; Sb, 0.163 ± 0.025; Sc, 0.0257 ± 0.0040; Se, 1.243 ± 0.079; and Zn, 1235 ± 92. It was observed that in BPH tissue, the mass fraction of Co (p < 0.015), Cr (p < 0.0002), Hg (p < 0.000007), K (p < 0.001), Rb (p < 0.048), Sb (p < 0.0001), and Se (p < 0.000001) were significantly higher than in controls. In the sixth to eighth decades, the mass fractions of almost all chemical elements in hyperplastic prostates did not depend from age. Our finding of correlation between pairs of prostatic chemical element mass fractions indicates that there is a great disturbance of prostatic chemical element relationships with a benign hyperplastic transformation. The results apparently confirm the disturbed homeostasis of Zn and Se and some other chemical elements in the etiology of BPH.
为了阐明增生性前列腺（良性前列腺增生症（BPH）患者，n = 32）和非增生性前列腺（健康男性居民对照组，n = 32）中银（Ag）、溴（Br）、钙（Ca）、钴（Co）、铬（Cr）、铁（Fe）、汞（Hg）、钾（K）、镁（Mg）、锰（Mn）、钠（Na）、铷（Rb）、锑（Sb）、钪（Sc）、硒（Se）和锌（Zn）含量的差异，进行了仪器中子活化分析。BPH患者腺体中化学元素质量分数（mg/kg，以干质量计）的平均值（M±SEM）如下：Ag，0.0346±0.0060；Br，30.4±3.6；Ca，2030±165；Co，0.0716±0.0097；Cr，1.073±0.119；Fe，130.0±7.9；Hg，0.232±0.030；K，14470±740；Mg，1200±80；Mn，1.19±0.09；Na，11610±870；Rb，14.7±0.8；Sb，0.163±0.025；Sc，0.0257±0.0040；Se，1.243±0.079；Zn，1235±92。观察到在BPH组织中，Co（p < 0.015）、Cr（p < 0.0002）、Hg（p < 0.000007）、K（p < 0.001）、Rb（p < 0.048）、Sb（p < 0.0001）和Se（p < 0.000001）的质量分数显著高于对照组。在第六至第八个十年中，增生性前列腺中几乎所有化学元素的质量分数与年龄无关。我们对前列腺化学元素质量分数对之间相关性的研究结果表明，良性增生性转变导致前列腺化学元素关系受到极大干扰。结果显然证实了BPH病因中锌和硒以及其他一些化学元素的内稳态受到干扰。
