Koyanagi T
Department of Orthopedic Surgery, School of Medicine, Keio University, Tokyo, Japan.
Nihon Seikeigeka Gakkai Zasshi. 1989 May;63(5):549-61.
We have studied the mechanical properties of enzyme-injected canine intervertebral discs by quasi-static compression tests, dynamic vibration tests and histology at 2 weeks (short-period group) and within 6 months (long-period group) after enzyme injection. The findings of each group were compared with those of normal discs as a control. The results were as follows; The quasi-static tests: In the short-period group, normalized stiffness of the discs was reduced significantly and the normalized creep rate was increased. The intradiscal pressures produced by external loading in short-period discs were almost half those of the control. In the long-period group such values tended to recover partially. The dynamic tests: In the short-period group, both elasticity and viscosity were reduced, while in the long-period group elasticity recovered but viscosity did not. These findings suggest that the shock-absorbing ability of enzyme-injected discs does not recover.
我们通过准静态压缩试验、动态振动试验和组织学方法，研究了酶注射后2周（短期组）和6个月内（长期组）犬椎间盘的力学性能。将每组的研究结果与作为对照的正常椎间盘进行比较。结果如下：准静态试验：在短期组中，椎间盘的归一化刚度显著降低，归一化蠕变率增加。短期组椎间盘在外加载荷作用下产生的椎间盘内压力几乎是对照组的一半。在长期组中，这些数值倾向于部分恢复。动态试验：在短期组中，弹性和粘性均降低，而在长期组中弹性恢复但粘性未恢复。这些研究结果表明，酶注射椎间盘的减震能力无法恢复。
