Cao Hua, Lei Sai, Li Naiying, Chen Longbin, Liu Jingyun, Cai Huiyin, Qiu Shuxian, Tan Jingwen
School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University, Zhongshan 528458, P.R. China.
Chem Commun (Camb). 2015 Feb 4;51(10):1823-5. doi: 10.1039/c4cc09134e.
Using the widely available DMSO as the formylation reagent under oxidative conditions, an efficient Cu-catalyzed C3-formylation reaction of imidazo[1,2-a]pyridine C-H bonds to directly generate structurally sophisticated 3-formyl imidazo[1,2-a]pyridine derivatives has been developed. The reaction proceeded to generate products in good yields, and used the environmentally friendly molecular oxygen as the oxidant.
在氧化条件下，使用广泛可得的二甲基亚砜作为甲酰化试剂，开发了一种高效的铜催化咪唑并[1,2-a]吡啶C-H键的C3-甲酰化反应，可直接生成结构复杂的3-甲酰基咪唑并[1,2-a]吡啶衍生物。该反应能够以良好的产率生成产物，并使用环境友好的分子氧作为氧化剂。
