Jiang Jun, Quan Xun-Feng, Zhang Li, Shen Li, Zhang Ming-Xia, Ma Hui-Hui, Wang Yi-Chun
The First Affiliated Hospital of Anhui Medical University, Anhui, Hefei, PR China ; Department of Radiation Oncology, The First Affiliated Hospital of Anhui Medical University, Anhui, Hefei, PR China.
Department of Radiation Oncology, The First Affiliated Hospital of Anhui Medical University, Anhui, Hefei, PR China.
Contemp Oncol (Pozn). 2014;18(3):177-81. doi: 10.5114/wo.2014.41394. Epub 2014 Jun 18.
Results of recent published studies on the association between the COX-2 8473T>C polymorphism and the risk of breast cancer have often been conflicting. To make a more precise estimation of the potential relationship, a meta-analysis was performed.
A total of seven case-control studies with 7,033 cases and 9,350 controls were included in the current meta-analysis through searching the databases of PubMed, Embase, and Cochrane Library (up to March 1(st), 2013). The odds ratio (OR) and 95% confidence interval (95% CI) were calculated to assess the strength of the association. The meta-analysis was conducted in a fixed/random effect model.
We found no significant associations for all genetic models after all studies were pooled into the meta-analysis (for C vs. T: OR = 0.974, 95% CI: 0.906-1.047, p = 0.471; for CC vs. TT: OR = 0.957, 95% CI: 0.803-1.140, p = 0.62; for TC vs. TT: OR = 0.964, 95% CI: 0.881-1.055, p = 0.421; for CC + TC vs. TT: OR = 0.963, 95% CI: 0.880-1.053, p = 0.406; for CC vs. TT + TC: OR = 0.978, 95% CI: 0.831-1.15, p = 0.788). We also observed no obvious associations in the subgroup analyses by ethnicity (Caucasian) and source of controls (population based, PB) for all genetic models.
Current evidence suggests that the COX-2 8473T>C polymorphism is not associated with breast cancer risk.
近期发表的关于COX - 2 8473T>C多态性与乳腺癌风险之间关联的研究结果常常相互矛盾。为了更精确地评估潜在关系，我们进行了一项荟萃分析。
通过检索PubMed、Embase和Cochrane图书馆数据库（截至2013年3月1日），本荟萃分析共纳入了7项病例对照研究，其中病例7033例，对照9350例。计算比值比（OR）和95%置信区间（95%CI）以评估关联强度。荟萃分析采用固定/随机效应模型进行。
在将所有研究纳入荟萃分析后，我们发现所有遗传模型均无显著关联（C对T：OR = 0.974，95%CI：0.906 - 1.047，p = 0.471；CC对TT：OR = 0.957，95%CI：0.803 - 1.140，p = 0.62；TC对TT：OR = 0.964，95%CI：0.881 - 1.055，p = 0.421；CC + TC对TT：OR = 0.963，95%CI：0.880 - 1.053，p = 0.406；CC对TT + TC：OR = 0.978，95%CI：0.831 - 1.15，p = 0.788）。在按种族（白种人）和对照来源（基于人群，PB）进行的亚组分析中，所有遗传模型也均未观察到明显关联。
当前证据表明，COX - 2 8473T>C多态性与乳腺癌风险无关。
