Miceli-Richard Corinne
Université Paris-Sud, hôpitaux universitaires Paris-Sud, AP-HP, 94275 Le Kremlin-Bicêtre, France; Institut National de la santé et de la recherche médicale (Inserm) U1012, 94275 Le Kremlin-Bicêtre, France.
Joint Bone Spine. 2015 Mar;82(2):90-3. doi: 10.1016/j.jbspin.2014.03.004. Epub 2014 Dec 15.
Systemic lupus erythematosus (SLE) is among the systemic autoimmune diseases whose complex pathogenesis involves both genetic and environmental factors. Epigenetic dysregulation resulting in overexpression of certain genes in some of the key immune cells, such as T cells, has been incriminated in the pathophysiology of SLE. Epigenetics is defined as transmissible and reversible modifications in gene expression without alterations in the nucleotide sequences. Epigenetic information is carried chiefly by DNA itself, histones, and noncoding RNAs. Several epigenetic mechanisms may play a role in SLE pathogenesis. This review discusses the various epigenetic mechanisms that regulate gene expression and provides examples relevant to SLE.
系统性红斑狼疮（SLE）是一种系统性自身免疫性疾病，其复杂的发病机制涉及遗传和环境因素。表观遗传失调导致某些关键免疫细胞（如T细胞）中某些基因的过表达，这已被认为与SLE的病理生理学有关。表观遗传学被定义为基因表达中的可传递和可逆修饰，而核苷酸序列不发生改变。表观遗传信息主要由DNA本身、组蛋白和非编码RNA携带。几种表观遗传机制可能在SLE发病机制中起作用。本综述讨论了调节基因表达的各种表观遗传机制，并提供了与SLE相关的实例。
