蛋白质组学在研究HIV-1与宿主蛋白相互作用中的应用
Proteomics in the investigation of HIV-1 interactions with host proteins.
作者信息
Li Ming
机构信息
Laboratory of Retrovirology, Division of Infectious Diseases, Department of Medicine, Alpert Medical School of Brown University, Providence, RI, USA.
出版信息
Proteomics Clin Appl. 2015 Feb;9(1-2):221-34. doi: 10.1002/prca.201400101. Epub 2015 Jan 19.
Abstract
Productive HIV-1 infection depends on host machinery, including a broad array of cellular proteins. Proteomics has played a significant role in the discovery of HIV-1 host proteins. In this review, after a brief survey of the HIV-1 host proteins that were discovered by proteomic analyses, I focus on analyzing the interactions between the virion and host proteins, as well as the technologies and strategies used in those proteomic studies. With the help of proteomics, the identification and characterization of HIV-1 host proteins can be translated into novel antiretroviral therapeutics.
摘要
高效的HIV-1感染依赖于宿主机制，包括多种细胞蛋白。蛋白质组学在发现HIV-1宿主蛋白方面发挥了重要作用。在本综述中，在简要概述通过蛋白质组学分析发现的HIV-1宿主蛋白之后，我将重点分析病毒体与宿主蛋白之间的相互作用，以及这些蛋白质组学研究中使用的技术和策略。借助蛋白质组学，HIV-1宿主蛋白的鉴定和表征可转化为新型抗逆转录病毒疗法。
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