Clinical Research, NeuroResearch Clinics, Inc., Cape Coral, FL, USA.
Stein Orthopedic Associates, Plantation, FL, USA.
Neuropsychiatr Dis Treat. 2014 Dec 10;10:2331-7. doi: 10.2147/NDT.S74952. eCollection 2014.
Urinary dopamine fluctuations in the competitive inhibition state were first documented in 2009. At that time, it was noted that progressively higher daily dosing values of L-tyrosine decreased the magnitude of these fluctuations. While extensive statistical analysis has been performed by the authors since 2004, it was not until 2012 that a plausible explanation was formulated. In the process, correlations with L-tyrosine administration and the on/off effect of Parkinson's disease were defined. This paper documents the current knowledge with regard to the management of retrograde phase 1 dopamine fluctuations and investigates the hypothesis that they are caused by a melanin steal phenomenon.
2009 年首次记录到竞争抑制状态下的尿多巴胺波动。当时，人们注意到，L-酪氨酸的每日剂量逐渐增加会降低这些波动的幅度。自 2004 年以来，作者已经进行了广泛的统计分析，但直到 2012 年才提出了一个合理的解释。在此过程中，与 L-酪氨酸给药和帕金森病的开/关效应相关联。本文记录了目前关于逆行相 1 多巴胺波动管理的知识，并研究了它们是由黑色素窃取现象引起的假说。
