Rizzoli R, Bonjour J P
Département de médecine, Hôpital cantonal universitaire, Genève.
Schweiz Med Wochenschr. 1989 Aug 19;119(33):1099-105.
Certain patients with malignant hypercalcemia display enhanced bone resorption and changes in renal tubular handling of calcium and phosphate similar to those encountered in primary hyperparathyroidism. A tumoral protein probably responsible for this syndrome has recently been described. Produced by a gene other than that of parathyroid hormone, it shows an aminoterminal homology with the physiological hormone. In some respect both proteins exert similar effects. This parathyroid hormone-analogue may also be involved in physiological regulatory functions.
某些恶性高钙血症患者表现出骨吸收增强以及肾小管对钙和磷的处理发生变化，类似于原发性甲状旁腺功能亢进症中所见到的情况。最近描述了一种可能导致这种综合征的肿瘤蛋白。它由甲状旁腺激素基因以外的基因产生，在氨基末端与生理激素具有同源性。在某些方面，这两种蛋白质发挥相似的作用。这种甲状旁腺激素类似物也可能参与生理调节功能。
