Huwyler T, Wüthrich B, Mühlethaler K, Kuhn H, Jungbluth H, Späth P, Hochreutener H
Allergiestation der Dermatologischen Universitätsklinik Zürich.
Schweiz Med Wochenschr. 1989 Sep 16;119(37):1253-6.
Two cases of enalapril(Reniten)-induced angioedema are described. In both patients the time lag between the first manifestation of angio-edema and diagnosis was more than one year, during which several bouts of edema occurred. One patient developed life-threatening swelling of the tongue and the larynx followed by asystole and apnea. The second patient had recurrent edema of the tongue and dyspnea. In general, enalapril-induced edema is not thought to be based on immunological mechanisms. However, in both patients we found elevated titres of antinuclear antibodies, which were reversible upon cessation of enalapril medication. The possible pathomechanisms are discussed.
描述了两例依那普利（Reniten）诱发的血管性水肿病例。两名患者血管性水肿首次出现至诊断的时间间隔均超过一年，在此期间发生了数次水肿发作。一名患者出现危及生命的舌部和喉部肿胀，随后出现心搏停止和呼吸暂停。第二名患者反复出现舌部水肿和呼吸困难。一般认为，依那普利诱发的水肿并非基于免疫机制。然而，在两名患者中我们均发现抗核抗体滴度升高，停用依那普利药物后滴度恢复正常。文中讨论了可能的发病机制。
