体重指数变化会增加早期乳腺癌女性的复发风险。
BMI variation increases recurrence risk in women with early-stage breast cancer.
作者信息
Fedele Palma, Orlando Laura, Schiavone Paola, Quaranta Annamaria, Lapolla Assunta Maria, De Pasquale Maria, Ardizzone Antonino, Bria Emilio, Sperduti Isabella, Calvani Nicola, Marino Antonella, Caliolo Chiara, Mazzoni Enrica, Cinieri Saverio
机构信息
Medical Oncology & Breast Unit, 'A Perrino' Hospital, SS 7 Appia, 72100 Brindisi, Italy.
出版信息
Future Oncol. 2014 Dec;10(15):2459-68. doi: 10.2217/fon.14.180.
AIMS
The prognostic role of BMI variation during and/or after treatments for early-stage breast cancer is still unknown.
PATIENTS & METHODS: The χ(2) test was conducted to explore the correlation between breast cancer recurrence and BMI changes in 520 early-stage breast cancer patients. Cox proportional hazard models were used to analyze the association of BMI changes, baseline BMI, known prognostic factors and recurrences.
RESULTS
BMI gain was significant determinant of recurrences (p = 0.0008). In multivariate analyses, BMI variation more than 5.71% was associated with higher rates of recurrences, as well as age less than 55 years, stage disease and molecular subtype.
CONCLUSION
Women who experience BMI gain after breast cancer may be at increased risk of poor outcomes.
目的
早期乳腺癌治疗期间和/或治疗后体重指数（BMI）变化的预后作用仍不明确。
患者与方法
采用χ²检验探讨520例早期乳腺癌患者中乳腺癌复发与BMI变化之间的相关性。使用Cox比例风险模型分析BMI变化、基线BMI、已知预后因素与复发之间的关联。
结果
BMI增加是复发的重要决定因素（p = 0.0008）。在多因素分析中，BMI变化超过5.71%与较高的复发率相关，同时还与年龄小于55岁、疾病分期和分子亚型有关。
结论
乳腺癌后BMI增加的女性可能预后不良风险增加。
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