醋酸盐为癌细胞供能。
Acetate fuels the cancer engine.
机构信息
Meyer Cancer Center, Department of Medicine, Weill Cornell Medical College, New York City, NY 10065, USA.
出版信息
Cell. 2014 Dec 18;159(7):1492-4. doi: 10.1016/j.cell.2014.12.009.
PMID:25525870
Abstract
Cancer cells have distinctive nutrient demands to fuel growth and proliferation, including the disproportionate use of glucose, glutamine, and fatty acids. Comerford et al. and Mashimo et al. now demonstrate that several types of cancer are avid consumers of acetate, which facilitates macromolecular biosynthesis and histone modification.
摘要
癌细胞有独特的营养需求来促进生长和增殖，包括葡萄糖、谷氨酰胺和脂肪酸的不成比例利用。Comerford 等人和 Mashimo 等人现在证明，几种类型的癌症是醋酸盐的狂热消费者，这有助于大分子生物合成和组蛋白修饰。
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