利用尿表皮生长因子和肾损伤分子1水平测定肾盂输尿管连接部梗阻的严重程度。
Determination of the severity of ureteropelvic junction obstruction using urinary epidermal growth factor and kidney injury molecule 1 levels.
作者信息
Mohammadjafari Hamid, Rafiei Alireza, Kosaryan Mehrnoush, Yeganeh Yalda, Hosseinimehr Seyed Jalal
机构信息
Antimicrobial Resistant Nosocomial Infection Research Center, Mazandaran University of Medical Sciences, Sari, Iran.
出版信息
Biomark Med. 2014;8(10):1199-206. doi: 10.2217/bmm.14.79.
AIM
This study aimed to assess the urinary concentrations of epidermal growth factor (EGF) and kidney injury molecule 1 (KIM-1) in patients with hydronephrosis.
METHODS
Neonates with a history of prenatal hydronephrosis were enrolled in three groups. Group 1 included neonates with severe obstruction; group 2 included neonates with milder obstruction; and group 3 included neonates with normal findings on postnatal ultrasonography.
RESULTS
59 neonates were enrolled. The EGF: Cr and KIM-1: Cr ratios were significantly higher in group 1 than in group 2 (p = 0.016 and 0.015, respectively). The cut-off values were measured as 16.855 (sensitivity 71%, specificity 77%) and 0.4765 (sensitivity 81%, specificity 71%) for EGF:Cr and KIM-1:Cr ratios, respectively. The values were significantly higher in group 1 than in group 2.
CONCLUSIONS
Evaluation of the urinary KIM-1:Cr ratio may help identify neonates with severe obstructive hydronephrosis.
目的
本研究旨在评估肾积水患者尿液中表皮生长因子（EGF）和肾损伤分子1（KIM-1）的浓度。
方法
有产前肾积水病史的新生儿被纳入三组。第1组包括严重梗阻的新生儿；第2组包括梗阻较轻的新生儿；第3组包括出生后超声检查结果正常的新生儿。
结果
共纳入59例新生儿。第1组的EGF:Cr和KIM-1:Cr比值显著高于第2组（分别为p = 0.016和0.015）。EGF:Cr和KIM-1:Cr比值的截断值分别为16.855（敏感性71%，特异性77%）和0.4765（敏感性81%，特异性71%）。第1组的值显著高于第2组。
结论
评估尿KIM-1:Cr比值可能有助于识别患有严重梗阻性肾积水的新生儿。
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