儿茶酚-O-甲基转移酶rs4680基因型与心脏直视手术后急性肾损伤及肾小管应激相关性的初步研究。

Pilot study of association of catechol-O-methyl transferase rs4680 genotypes with acute kidney injury and tubular stress after open heart surgery.

作者信息

Albert Christian, Kube Johanna, Haase-Fielitz Anja, Dittrich Annemarie, Schanze Denny, Zenker Martin, Kuppe Hermann, Hetzer Roland, Bellomo Rinaldo, Mertens Peter R, Haase Michael

机构信息

Department of Nephrology & Hypertension, Diabetes & Endocrinology, Otto-von-Guericke University, Magdeburg, Germany.

出版信息

Biomark Med. 2014;8(10):1227-38. doi: 10.2217/bmm.14.85.

DOI:10.2217/bmm.14.85

PMID:25525983

Abstract

AIM

To assess the association of genetic variants of catecholamine-O-methyltransferase (COMT) genotypes with acute kidney injury (AKI) and tubular stress after open heart surgery.

PATIENTS & METHODS: We genotyped 195 patients for the COMT-Val158Met polymorphism and measured creatinine, neutrophil gelatinase-associated lipocalin and midkine. We analyzed the association between such polymorphisms and these kidney-related variables.

RESULTS

Nonsignificantly more COMT LL patients developed RIFLE-AKI compared with non-LL patients (p = 0.11). Compared with HL and HH patients, LL patients who developed AKI had lower increases in serum creatinine. COMT LL patients had less pronounced release of tubular stress biomarkers (neutrophil gelatinase-associated lipocalin: p = 0.045, midkine: p = 0.072).

CONCLUSION

COMT genotype may associate with different patterns of renal functional changes and tubular stress biomarker release response after open heart surgery.

摘要

目的

评估儿茶酚-O-甲基转移酶（COMT）基因多态性与心脏直视手术后急性肾损伤（AKI）及肾小管应激之间的关联。

患者与方法

我们对195例患者进行了COMT-Val158Met多态性基因分型，并测量了肌酐、中性粒细胞明胶酶相关脂质运载蛋白和中期因子。我们分析了此类多态性与这些肾脏相关变量之间的关联。

结果

与非LL患者相比，COMT LL患者发生RIFLE-AKI的比例略高，但无统计学意义（p = 0.11）。与HL和HH患者相比，发生AKI的LL患者血清肌酐升高幅度较低。COMT LL患者肾小管应激生物标志物的释放不太明显（中性粒细胞明胶酶相关脂质运载蛋白：p = 0.045，中期因子：p = 0.072）。