Department of Frontier Materials, Graduate School of Engineering, Nagoya Institute of Technology , Gokiso, Showa-ku, Nagoya 466-8555, Japan.
Org Lett. 2015 Jan 2;17(1):106-9. doi: 10.1021/ol503309s. Epub 2014 Dec 19.
The first catalytic enantioselective addition of thiols to ketimines derived from isatins has been developed. Excellent yields and enantioselectivities were observed for the reaction of various ketimines and thiols using a cinchona alkaloid sulfonamide catalyst. Both enantiomers of products could be obtained by using pseudoenantiomeric chiral catalysts.
首次发展了手性催化剂催化的硫醇与色满酮亚胺的对映选择性加成反应。使用金鸡纳生物碱磺酰胺催化剂，该反应对各种色满酮亚胺和硫醇具有优异的产率和对映选择性。通过使用假对映异构体手性催化剂，可以得到产物的两种对映异构体。
