Schriever V A, Boerner C, Mori E, Smitka M, Hummel T
Smell & Taste Clinic, Department of Otorhinolaryngology, Technical University of Dresden, Dresden, Germany; Department of Neuropediatrics, University Hospital Carl Gustav Carus, TU Dresden, Germany.
Smell & Taste Clinic, Department of Otorhinolaryngology, Technical University of Dresden, Dresden, Germany.
Neuroscience. 2015 Feb 26;287:15-22. doi: 10.1016/j.neuroscience.2014.12.012. Epub 2014 Dec 16.
Olfactory event-related potentials (OERPs) are widely used to study central odor processing. Only a few studies used this method in children and adolescents. Aim of the current study therefore was to measure OERP and the possible influences of age and sex on central odor processing in this age group.
A total of 81 children between 6 and 17 years of age were included in this study. OERP in response to a rose-like odor were measured from three recording positions (Fz, Cz, Pz) according to the 10-20 system. Stimuli were presented by means of a computer-controlled olfactometer.
Age had a significant influence on the amplitudes of the late positivity with younger children showing larger amplitudes. Although age did not significantly affect the latencies of OERP, interactions of recording positions and latencies between younger and older children and between girls and boys were found.
OERP can be used to study central odor processing in children older than 6 years of age. Central odor processing changes from childhood to adolescents possibly reflecting maturation of the brain.
嗅觉事件相关电位（OERPs）被广泛用于研究中枢嗅觉处理。仅有少数研究在儿童和青少年中使用此方法。因此，本研究的目的是测量该年龄组的OERP以及年龄和性别对中枢嗅觉处理的可能影响。
本研究共纳入81名6至17岁的儿童。根据10-20系统，从三个记录位置（Fz、Cz、Pz）测量对玫瑰样气味的OERP。刺激通过计算机控制的嗅觉计呈现。
年龄对晚期正波的波幅有显著影响，年龄较小的儿童波幅较大。虽然年龄对OERP的潜伏期没有显著影响，但发现了年龄较小与较大儿童之间以及女孩与男孩之间记录位置和潜伏期的相互作用。
OERP可用于研究6岁以上儿童的中枢嗅觉处理。中枢嗅觉处理从儿童期到青少年期发生变化，可能反映了大脑的成熟。
