Silva Liliana J G, Pereira André M P T, Meisel Leonor M, Lino Celeste M, Pena Angelina
REQUIMTE, Group of Bromatology, Pharmacognosy and Analytical Sciences, Faculty of Pharmacy, University of Coimbra, Polo III, Azinhaga de Stª Comba, 3000-548 Coimbra, Portugal.
REQUIMTE, Group of Bromatology, Pharmacognosy and Analytical Sciences, Faculty of Pharmacy, University of Coimbra, Polo III, Azinhaga de Stª Comba, 3000-548 Coimbra, Portugal.
Environ Pollut. 2015 Feb;197:127-143. doi: 10.1016/j.envpol.2014.12.002. Epub 2014 Dec 18.
Selective serotonin re-uptake inhibitors (SSRIs) antidepressants are amongst the most prescribed pharmaceutical active substances throughout the world. Their presence, already described in different environmental compartments such as wastewaters, surface, ground and drinking waters, and sediments, and their remarkable effects on non-target organisms justify the growing concern about these emerging environmental pollutants. A comprehensive review of the literature data with focus on their footprint in the aquatic biota, namely their uptake, bioaccumulation and both acute and chronic ecotoxicology is presented. Long-term multigenerational exposure studies, at environmental relevant concentrations and in mixtures of related compounds, such as oestrogenic endocrine disruptors, continue to be sparse and are imperative to better know their environmental impact.
选择性5-羟色胺再摄取抑制剂（SSRIs）类抗抑郁药是全球处方量最多的药物活性物质之一。它们已在不同环境介质中被发现，如废水、地表水、地下水、饮用水和沉积物，并且它们对非目标生物具有显著影响，这使得人们对这些新兴环境污染物的担忧日益增加。本文对文献数据进行了全面综述，重点关注它们在水生生物群中的踪迹，即它们的摄取、生物累积以及急性和慢性生态毒理学。在环境相关浓度下以及在相关化合物（如雌激素内分泌干扰物）混合物中的长期多代暴露研究仍然很少，而此类研究对于更好地了解它们的环境影响至关重要。
