Sosnowski M, Yaksh T L
Department of Anesthesiology, University of California, San Diego, La Jolla.
Anesth Analg. 1989 Nov;69(5):587-92.
The intrathecal administration of strychnine in rats yields a prominent touch-evoked allodynia. The effects of an intrathecally administered A1 adenosine agonist: N6-(L-2-phenylisopropyl)-adenosine (LPIA) or an A2 adenosine agonist: 5'-(N-ethyl carboxamido)-adenosine (NECA), on this touch-evoked hyperesthesia were examined. Over the range of 0.3-1.0 nmol these agents produced a dose-dependent inhibition of the strychnine-evoked hyperesthesia. This inhibition was reversed following intraperitoneal injection of caffeine, an adenosine receptor antagonist. No statistical differences between LPIA and NECA were recorded. The powerful effect of adenosine analogues on strychnine hyperesthesia occur at doses that have only a mild analgesic effect on the thermally evoked hot-plate response. This effect is in contrast to opioids, which have been reported to be only minimally effective against strychnine-evoked hyperesthesia. The characteristics of the strychnine hyperesthesia appear to mimic the clinical phenomenon observed in patients suffering from sensory dysesthesia following nerve injury and suggest a possible role for the adenosine receptor in certain pain states.
给大鼠鞘内注射士的宁会产生明显的触觉诱发痛觉过敏。研究了鞘内注射A1腺苷激动剂：N6-(L-2-苯异丙基)-腺苷（LPIA）或A2腺苷激动剂：5'-(N-乙基甲酰胺基)-腺苷（NECA）对这种触觉诱发的感觉过敏的影响。在0.3 - 1.0纳摩尔范围内，这些药物对士的宁诱发的感觉过敏产生剂量依赖性抑制。腹腔注射腺苷受体拮抗剂咖啡因后，这种抑制作用被逆转。未记录到LPIA和NECA之间的统计学差异。腺苷类似物对士的宁感觉过敏的强大作用发生在对热诱发热板反应仅有轻微镇痛作用的剂量下。这种作用与阿片类药物相反，据报道阿片类药物对士的宁诱发的感觉过敏效果甚微。士的宁感觉过敏的特征似乎模拟了神经损伤后感觉异常患者中观察到的临床现象，并提示腺苷受体在某些疼痛状态中可能发挥作用。
