立体特异性配体及其配合物。二十二。钯（II）与（S，S）-乙二胺-N，N'-二-（2，2'-二（4-羟基苄基））-乙酸的某些酯的配合物的合成及抗肿瘤活性
Stereospecific ligands and their complexes. XXII. Synthesis and antitumor activity of palladium(II) complexes with some esters of (S,S)-ethylenediamine-N,N'-di-(2,2'-di(4-hydroxy-benzyl))-acetic acid.
作者信息
Stojković Danijela Lj, Jevtić Verica V, Radić Gordana P, Todorović Danijela V, Petrović Marija, Zarić Milan, Nikolić Ivana, Baskić Dejan, Trifunović Srećko R
机构信息
Department of Chemistry, Faculty of Science, University of Kragujevac, Radoja Domanovića 12, 34000 Kragujevac, Serbia.
Department of Chemistry, Faculty of Science, University of Kragujevac, Radoja Domanovića 12, 34000 Kragujevac, Serbia.
出版信息
J Inorg Biochem. 2015 Feb;143:111-6. doi: 10.1016/j.jinorgbio.2014.12.001. Epub 2014 Dec 10.
Four new ligands and their palladium(II) complexes of general formula R2-S,S-eddtyr (L1-L4) and [PdCl2(R2-S,S-eddtyr)] (C1-C4) (R=ethyl, n-propyl, n-butyl and n-pentyl; S,S-eddtyr·2HCl=ethylenediamine-N,N'-di-(2,2'-di(4-hydroxy-benzyl))-acetic acid dihydrochloride have been synthesized and characterized by microanalysis, infrared, (1)H and (13)C NMR spectroscopy. Cytotoxicity for ligands and complexes on two different cell lines (human breast cancer, MDA-MB-231 and human lung cancer, A549 cell lines) and human chronic lymphocytic leukemia cells (CLL) was investigated using MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) assay.
合成了四种通式为R2-S,S-eddtyr（L1-L4）和[PdCl2(R2-S,S-eddtyr)]（C1-C4）的新配体及其钯（II）配合物（R = 乙基、正丙基、正丁基和正戊基；S,S-eddtyr·2HCl = 乙二胺-N,N'-二-(2,2'-二(4-羟基苄基))-乙酸二盐酸盐），并通过微量分析、红外光谱、（1）H和（13）C NMR光谱对其进行了表征。使用MTT（3-[4,5-二甲基噻唑-2-基]-2,5-二苯基四氮唑溴盐）分析法研究了配体和配合物对两种不同细胞系（人乳腺癌MDA-MB-231细胞系和人肺癌A549细胞系）以及人慢性淋巴细胞白血病细胞（CLL）的细胞毒性。
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