Mecawi Andre S, Macchione Ana F, Nuñez Paula, Perillan Carmen, Reis Luis C, Vivas Laura, Arguelles Juan
Department of Physiological Sciences, Institute of Biology, Federal Rural University of Rio de Janeiro, Seropedica, Brazil; Department of Physiology, Faculty of Medicine, University of Malaysia, Kuala Lumpur, Malaysia.
Institute of Medical Investigation Mercedes and Martín Ferreyra, INIMEC-CONICET-National University of Cordoba, Cordoba, Argentina; Department of Cellular Biology, Faculty of Dentistry, National University of Cordoba, Córdoba, Argentina.
Neurosci Biobehav Rev. 2015 Apr;51:1-14. doi: 10.1016/j.neubiorev.2014.12.012. Epub 2014 Dec 17.
Thirst and sodium appetite are the sensations responsible for the motivated behaviors of water and salt intake, respectively, and both are essential responses for the maintenance of hydromineral homeostasis in animals. These sensations and their related behaviors develop very early in the postnatal period in animals. Many studies have demonstrated several pre- and postnatal stimuli that are responsible for the developmental programing of thirst and sodium appetite and, consequently, the pattern of water and salt intake in adulthood in need-free or need-induced conditions. The literature systematically reports the involvement of dietary changes, hydromineral and cardiovascular challenges, renin-angiotensin system and steroid hormone disturbances, and lifestyle in these developmental factors. Therefore, this review will address how pre- and postnatal challenges can program lifelong thirst and sodium appetite in animals and humans, as well as which neuroendocrine substrates are involved. In addition, the possible epigenetic molecular mechanisms responsible for the developmental programing of drinking behavior, the clinical implications of hydromineral disturbances during pre- and postnatal periods, and the developmental origins of adult hydromineral behavior will be discussed.
口渴和摄盐欲分别是引发动物饮水和摄盐这两种行为动机的感觉，二者都是动物维持水盐平衡的重要反应。这些感觉及其相关行为在动物出生后的早期阶段就已形成。许多研究已经证实了几种产前和产后刺激因素，它们负责口渴和摄盐欲的发育编程，进而决定了成年动物在无需求或有需求情况下的饮水和摄盐模式。文献系统地报道了饮食变化、水盐及心血管挑战、肾素 - 血管紧张素系统和类固醇激素紊乱以及生活方式在这些发育因素中的作用。因此，本综述将探讨产前和产后挑战如何在动物和人类中对终身口渴和摄盐欲进行编程，以及涉及哪些神经内分泌底物。此外，还将讨论负责饮水行为发育编程的可能表观遗传分子机制、产前和产后阶段水盐紊乱的临床意义以及成年水盐行为的发育起源。
