Brauner E, Dănilă F, Rădulescu A, Turcu T, Vîntu C, Hurmuzache T, Vătavu C, Damir P, Colţea A, Bărăscu L, Gavriliţă L, Labă E, Zavate O, Cotor F, Ivan A
Rev Med Chir Soc Med Nat Iasi. 1981 Oct-Dec;85(4):629-34.
In May 1981 the hand, foot and mouth disease was diagnosed for the first time in Ramaia in a 4 year old child. The onset of the disease was characterized by moderate fever, coryza and spontaneous endobuccal pains followed at a short interval of time by the simultaneous of a papulo-vesicular eruption on hands and feet. The eruption was prevalent on the hands and feet fingers as well as on the palmar and plantar regions. Isolated aphthous lesions were seen on the vestibular mucosa. Morphologically, the intraepidermic site of the lesion with an advanced acantholytic process in the vesicular area was noticed. In the superficial and deep tissue perivascular infiltrate with mononucleares were present.
1981年5月，在拉马亚首次诊断出一名4岁儿童患有手足口病。该病起病时表现为中度发热、鼻炎和口腔内自发疼痛，短时间内随后手脚同时出现丘疹水疱疹。皮疹在手、脚的手指以及手掌和足底部位最为常见。在前庭黏膜可见孤立的口疮性病变。形态学上，可见病变位于表皮内，水疱区域有明显的棘层松解过程。在浅表和深部组织中有单核细胞的血管周围浸润。
