Cherniavskiĭ V V
Lik Sprava. 2014 Nov(11):76-82.
Maldigestion persists in most patients with chronic pancreatitis (GP). The objective lipase and amylase insufficiency diagnosis is needed to achieve an adequate clinical response to oral pancreatic enzyme substitution therapy. The novel data is presented in the article about the role of 13C-mixed triglyceride and 13C-corn starch breath tests as a tools for exocrine pancreatic insufficiency diagnosis, for evaluating fat and starch malabsorbtion in CP patients. 135 patients were included in the investigation. It has been shown, that 13C-breath tests could be useful tools in clinical practice for CP diagnosis. They are well correlate with fecal elastase-1 level, has high sensitivity and specificity for diagnosis of lipase and amylase deficiency. Tests make it possible to choose the initial pancreatic enzyme dosage and are beneficial during the treatment for pancreatic enzyme dose correction.
大多数慢性胰腺炎（CP）患者存在消化功能不良。为了使口服胰酶替代疗法获得充分的临床反应，需要客观地诊断脂肪酶和淀粉酶不足。本文介绍了有关13C混合甘油三酯和13C玉米淀粉呼气试验作为诊断外分泌性胰腺功能不全、评估CP患者脂肪和淀粉吸收不良工具的新数据。135名患者纳入了研究。结果表明，13C呼气试验可能是CP诊断临床实践中的有用工具。它们与粪便弹性蛋白酶-1水平密切相关，对脂肪酶和淀粉酶缺乏的诊断具有高敏感性和特异性。这些试验有助于选择初始胰酶剂量，并且在胰酶剂量校正治疗期间有益。
