肌肉健康与疾病中的Kruppel样因子。
Kruppel-like factors in muscle health and disease.
作者信息
Prosdocimo Domenick A, Sabeh M Khaled, Jain Mukesh K
机构信息
Case Cardiovascular Research Institute, Cleveland, OH; Harrington Heart & Vascular Institute, Cleveland, OH; Department of Medicine, University Hospitals Case Medical Center, Cleveland, OH; Case Western Reserve University School of Medicine and University Hospitals Case Medical Center, Cleveland, OH.
Case Cardiovascular Research Institute, Cleveland, OH; Harrington Heart & Vascular Institute, Cleveland, OH; Department of Medicine, University Hospitals Case Medical Center, Cleveland, OH; Case Western Reserve University School of Medicine and University Hospitals Case Medical Center, Cleveland, OH.
出版信息
Trends Cardiovasc Med. 2015 May;25(4):278-87. doi: 10.1016/j.tcm.2014.11.006. Epub 2014 Nov 15.
Abstract
Kruppel-like factors (KLF) are zinc-finger DNA-binding transcription factors that are critical regulators of tissue homeostasis. Emerging evidence suggests that KLFs are critical regulators of muscle biology in the context of cardiovascular health and disease. The focus of this review is to provide an overview of the current state of knowledge regarding the physiologic and pathologic roles of KLFs in the three lineages of muscle: cardiac, smooth, and skeletal.
摘要
Kruppel样因子（KLF）是锌指DNA结合转录因子，是组织稳态的关键调节因子。新出现的证据表明，在心血管健康和疾病背景下，KLF是肌肉生物学的关键调节因子。本综述的重点是概述目前关于KLF在心肌、平滑肌和骨骼肌这三种肌肉谱系中的生理和病理作用的知识状况。
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