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精氨酸加压素 1a 受体 RS3 启动子微卫星在精神分裂症中的作用：“风险”等位基因对临床症状和面部表情识别影响的研究。

Arginine vasopressin 1a receptor RS3 promoter microsatellites in schizophrenia: a study of the effect of the "risk" allele on clinical symptoms and facial affect recognition.

机构信息

Mental Health Research Center, Russian Academy of Medical Sciences, Kashirskoe sh. 34, Moscow 115522, Russia.

Mental Health Research Center, Russian Academy of Medical Sciences, Kashirskoe sh. 34, Moscow 115522, Russia.

出版信息

Psychiatry Res. 2015 Feb 28;225(3):739-40. doi: 10.1016/j.psychres.2014.11.043. Epub 2014 Dec 3.

DOI:10.1016/j.psychres.2014.11.043
PMID:25529259
Abstract

We studied AVPR1A RS3 polymorphism in schizophrenic patients and controls. AVPR1A RS3 was not associated with schizophrenia. The allele 327bp implicated in autism and social behavior was associated with negative symptoms and tended to be linked to patient facial affect recognition suggesting its impact on schizophrenia social phenotypes.

摘要

我们研究了精神分裂症患者和对照组中的 AVPR1A RS3 多态性。AVPR1A RS3 与精神分裂症无关。与自闭症和社交行为有关的等位基因 327bp 与阴性症状相关，并且倾向于与患者面部表情识别相关，表明其对精神分裂症社会表型的影响。

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