依那西普联合全身用药或光疗治疗银屑病。
Etanercept combined with systemic drugs or phototherapy for treatment of psoriasis.
作者信息
Ara M, Gracia T, Pastushenko E
机构信息
Servicio de Dermatología Hospital Clínico Universitario Lozano Blesa, Zaragoza, España.
Servicio de Dermatología Hospital Clínico Universitario Lozano Blesa, Zaragoza, España.
出版信息
Actas Dermosifiliogr. 2015 Apr;106(3):180-8. doi: 10.1016/j.ad.2014.09.003. Epub 2014 Dec 18.
Biologic drugs have provided excellent results in the treatment of moderate to severe psoriasis. Nevertheless, in routine clinical practice, combinations of biologic drugs with phototherapy or systemic drugs can increase efficacy, diminish toxicity, and reduce the cost of treatment. Published experience with these combinations is scarce, although the results are often satisfactory. This review examines the most relevant published experience in the combination of the most studied drug in this field-etanercept-with methotrexate, acitretin, ciclosporin, and narrowband UV-B phototherapy. Findings reported in the literature can help when taking major decisions on the management of biologic and systemic drugs in moderate to severe psoriasis.
生物药物在中重度银屑病的治疗中已取得了出色的效果。然而，在常规临床实践中，生物药物与光疗或全身性药物联合使用可提高疗效、降低毒性并减少治疗成本。尽管这些联合治疗的结果往往令人满意，但相关的公开经验却很少。本综述考察了该领域研究最多的药物——依那西普——与甲氨蝶呤、阿维A、环孢素及窄谱UV - B光疗联合使用的最相关公开经验。文献中报道的研究结果有助于在中重度银屑病生物药物和全身性药物治疗管理方面做出重大决策。
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