Wei Guo, Hua Xin, Zhao Yong, Hu Minghui, Gou Fang, Liu Lin, Cai Lin, He Yong, He Shenghua
Department of Surgery, Chengdu Public Health Clinic Care Center, Chengdu Infections Disease Hospital, Chengdu 610061, China.
Zhonghua Wei Chang Wai Ke Za Zhi. 2014 Dec;17(12):1201-4.
To explore the efficacy of Ruiyun procedure for hemorrhoids (RPH) combined with Xiaozhiling injection in the treatment of hemorrhoids complicated with human immunodeficiency virus (HIV) infection and its influence on cellular immune function.
Clinical data of 76 hemorrhoid patients, including 36 positive HIV and 40 negative HIV, undergoing RPH combined with Xiaozhiling injections in our center from January 2010 to December 2012 were retrospectively analyzed. Clinical efficacy and cellular immune function preoperative day 1, postoperative day 7, 30 were compared between positive and negative groups.
Recurrence rates of positive group and negative group postoperative 6 months were 22.2% (8/36) and 22.5% (9/40), postoperative 1 year were 30.6% (11/36) and 30.0% (12/40) without significant differences (all P>0.05). Morbidity of postoperative complication was also not significantly different between two groups (P>0.05). According to HIV classification, peripheral lymph cell ratio, CD4 count, CD4/CD8, white blood cell count and neutrophil ratio were not significantly different between preoperative day 1 and postoperative day 7 in both groups (all P>0.05). Decreasing velocity and amplitude of CD4 in both groups from high to low was HIV III, HIV II, HIV I, HIV-, while after 30 days the increase of CD4 from high to low was HIV-, HIV I, HIV II, HIV III, which were significantly different as compared to postoperative day 7 (all P<0.05).
RPH combined with Xiaozhiling injection in the treatment of hemorrhoids complicated with HIV infection is effective and safe. Postoperative inhibited cellular immune function can recover quickly.
探讨吻合器痔上黏膜环切术（RPH）联合消痔灵注射治疗合并人类免疫缺陷病毒（HIV）感染的痔的疗效及其对细胞免疫功能的影响。
回顾性分析2010年1月至2012年12月在本中心接受RPH联合消痔灵注射治疗的76例痔患者的临床资料，其中HIV阳性36例，HIV阴性40例。比较阳性组和阴性组术前1天、术后7天、30天的临床疗效及细胞免疫功能。
阳性组和阴性组术后6个月复发率分别为22.2%（8/36）和22.5%（9/40），术后1年分别为30.6%（11/36）和30.0%（12/40），差异无统计学意义（均P>0.05）。两组术后并发症发生率差异亦无统计学意义（P>0.05）。按HIV分期，两组术前1天与术后7天外周淋巴细胞比例、CD4计数、CD4/CD8、白细胞计数及中性粒细胞比例差异均无统计学意义（均P>0.05）。两组CD4从高到低下降速度和幅度依次为HIV III、HIV II、HIV I、HIV-，术后30天CD4升高幅度从高到低依次为HIV-、HIV I、HIV II、HIV III，与术后7天比较差异均有统计学意义（均P<0.05）。
RPH联合消痔灵注射治疗合并HIV感染的痔安全有效，术后受抑制的细胞免疫功能可较快恢复。
