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[The ectophosphatase activity of cultured endothelial cells of calf aorta and the effect of drugs on ecto-ATPase].

作者信息

Melzig M, Michalski H, Teuscher E

机构信息

Sektion Pharmazie, Ernst-Mortiz-Arndt-Universität Greifswald, DDR.

出版信息

Biomed Biochim Acta. 1989;48(7):431-6.

PMID:2553007
Abstract

Cultivated endothelial cells of calf aorta (line BKEz-7) possess an effective ectophosphatase system (enzyme activities: ATPase 38.0 +/- 10.2; ADPase 9.2 +/- 4.2; 5'-nucleotidase 4.1 +/- 2.6 fmol/cell.min). Drugs with central depressive activity such as promazine, chlorpromazine, and meprobamate inhibit the activity of the ecto-ATPase. A possible connection between the inhibitory activity on the ecto-ATPase and their central depressive effects is discussed.

摘要

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