Mijnarends Donja M, Schols Jos M G A, Meijers Judith M M, Tan Frans E S, Verlaan Sjors, Luiking Yvette C, Morley John E, Halfens Ruud J G
Department of Health Services Research, School CAPHRI, Maastricht University, Maastricht, The Netherlands.
Department of Health Services Research, School CAPHRI, Maastricht University, Maastricht, The Netherlands; Department of Family Medicine, School CAPHRI, Maastricht University, Maastricht, The Netherlands.
J Am Med Dir Assoc. 2015 Apr;16(4):301-8. doi: 10.1016/j.jamda.2014.11.011. Epub 2014 Dec 17.
Both sarcopenia and physical frailty are geriatric syndromes causing loss of functionality and independence. This study explored the association between sarcopenia and physical frailty and the overlap of their criteria in older people living in different community (care) settings. Moreover, it investigated the concurrent validity of the FRAIL scale to assess physical frailty, by comparison with the widely used Fried criteria.
Data were retrieved from the cross-sectional Maastricht Sarcopenia Study (MaSS).
The study was undertaken in different community care settings in an urban area (Maastricht) in the south of the Netherlands.
Participants were 65 years or older, gave written informed consent, were able to understand Dutch language, and were not wheelchair bound or bedridden.
Not applicable.
Sarcopenia was identified using the algorithm of the European Working Group on Sarcopenia in Older People. Physical frailty was assessed by the Fried criteria and by the FRAIL scale. Logistic regression was performed to assess the association between sarcopenia and physical frailty measured by the Fried criteria. Spearman correlation was performed to assess the concurrent validity of the FRAIL scale compared with the Fried criteria.
Data from 227 participants, mean age 74.9 years, were analyzed. Sarcopenia was identified in 23.3% of the participants, when using the cutoff levels for moderate sarcopenia. Physical frailty was identified in 8.4% (≥3 Fried criteria) and 9.3% (≥3 FRAIL scale criteria) of the study population. Sarcopenia and physical frailty were significantly associated (P = .022). Frail older people were more likely to be sarcopenic than those who were not frail. In older people who were not frail, the risk of having sarcopenia increased with age. Next to poor grip strength (78.9%) and slow gait speed (89.5%), poor performance in other functional tests was common in frail older people. The 2 physical frailty scales were significantly correlated (r = 0.617, P < .001).
Sarcopenia and physical frailty were associated and partly overlap, especially on parameters of impaired physical function. Some evidence for concurrent validity between the FRAIL scale and Fried criteria was found. Future research should elicit the value of combining sarcopenia and frailty measures in preventing disability and other negative health outcomes.
肌肉减少症和身体虚弱都是导致功能丧失和独立性缺失的老年综合征。本研究探讨了肌肉减少症与身体虚弱之间的关联，以及它们在不同社区（护理）环境中老年人的标准重叠情况。此外，通过与广泛使用的弗里德标准进行比较，研究了FRAIL量表评估身体虚弱的同时效度。
数据取自横断面的马斯特里赫特肌肉减少症研究（MaSS）。
该研究在荷兰南部城市地区（马斯特里赫特）的不同社区护理环境中进行。
参与者年龄在65岁及以上，签署了书面知情同意书，能够理解荷兰语，且非轮椅依赖或卧床不起。
不适用。
使用老年人肌肉减少症欧洲工作组的算法确定肌肉减少症。通过弗里德标准和FRAIL量表评估身体虚弱。进行逻辑回归以评估肌肉减少症与弗里德标准测量的身体虚弱之间的关联。进行斯皮尔曼相关性分析以评估FRAIL量表与弗里德标准相比的同时效度。
分析了227名参与者的数据，平均年龄74.9岁。使用中度肌肉减少症的临界值时，23.3%的参与者被确定患有肌肉减少症。在研究人群中，8.4%（≥3项弗里德标准）和9.3%（≥3项FRAIL量表标准）的人被确定为身体虚弱。肌肉减少症与身体虚弱显著相关（P = 0.022）。虚弱的老年人比非虚弱的老年人更有可能患有肌肉减少症。在非虚弱的老年人中，患肌肉减少症的风险随年龄增加。除握力差（78.9%）和步态速度慢（89.5%）外，其他功能测试表现不佳在虚弱的老年人中也很常见。两种身体虚弱量表显著相关（r = 0.617，P < 0.001）。
肌肉减少症与身体虚弱相关且部分重叠，尤其是在身体功能受损参数方面。发现了FRAIL量表与弗里德标准之间同时效度的一些证据。未来的研究应阐明将肌肉减少症和虚弱测量相结合在预防残疾和其他负面健康结果方面的价值。
