Mori Yasuo, Mori Masayuki X, Nishida Motohiro
Laboratory of Environmental Systems Biology, Graduate School of Environmental Studies and Laboratory of Molecular Biology, Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering Kyoto University, Japan.
Clin Calcium. 2015 Jan;25(1):47-58.
Calcium ion (Ca2+) is the only second messenger well recognized for the established biological role among various inorganic ions. When cellular Ca2+ controls diverse biological phenomena, it is regulated under exquisitely precise mechanisms. Many proteins have been identified as Ca2+ signal-regulating factors, and still new "players" are added to the repertory. In this review, we will focus on Ca2+ channels, Ca2+-binding proteins,and signaling pathways controlled by these Ca2+ signal-regulating proteins, in order to discuss on molecular bases, biological significance, and possible future developments of Ca2+ signaling.
钙离子（Ca2+）是众多无机离子中唯一因已确定的生物学作用而被广泛认可的第二信使。当细胞内的Ca2+控制着多种生物学现象时，它受到极其精确的机制调控。许多蛋白质已被确定为Ca2+信号调节因子，而且仍有新的“参与者”不断加入这一行列。在本综述中，我们将聚焦于Ca2+通道、Ca2+结合蛋白以及由这些Ca2+信号调节蛋白所控制的信号通路，以便探讨Ca2+信号传导的分子基础、生物学意义以及未来可能的发展方向。
