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本文引用的文献

1
Molecular mechanisms of preeclampsia.子痫前期的分子机制
Microvasc Res. 2008 Jan;75(1):1-8. doi: 10.1016/j.mvr.2007.04.009. Epub 2007 May 6.
2
Mapping the theories of preeclampsia: the need for systematic reviews of mechanisms of the disease.子痫前期理论的梳理：对该疾病发病机制进行系统评价的必要性。
Am J Obstet Gynecol. 2006 Feb;194(2):317-21. doi: 10.1016/j.ajog.2005.08.065.
3
Associations of polymorphisms of the angiotensinogen M235 polymorphism and angiotensin-converting-enzyme intron 16 insertion/deletion polymorphism with preeclampsia in Korean women.韩国女性中血管紧张素原M235多态性及血管紧张素转换酶内含子16插入/缺失多态性与子痫前期的相关性
Eur J Obstet Gynecol Reprod Biol. 2004 Sep 10;116(1):48-53. doi: 10.1016/j.ejogrb.2004.01.035.
4
Association of Angiotensin-converting enzyme and angiotensinogen gene polymorphisms with preeclampsia.血管紧张素转换酶及血管紧张素原基因多态性与子痫前期的关联
J Korean Med Sci. 2004 Apr;19(2):253-7. doi: 10.3346/jkms.2004.19.2.253.
5
Interaction between the polymorphisms of the renin-angiotensin system in preeclampsia.子痫前期中肾素-血管紧张素系统多态性之间的相互作用。
Eur J Obstet Gynecol Reprod Biol. 2003 Sep 10;110(1):8-11. doi: 10.1016/s0301-2115(03)00046-0.
6
Summary of the NHLBI Working Group on Research on Hypertension During Pregnancy.美国国立心肺血液研究所孕期高血压研究工作组总结
Hypertension. 2003 Mar;41(3):437-45. doi: 10.1161/01.HYP.0000054981.03589.E9. Epub 2003 Feb 10.
7
Conservative management of eclampsia and severe pre-eclampsia--A Bangladesh experience.子痫和重度子痫前期的保守治疗——孟加拉国的经验
Medscape Womens Health. 2002 Jan;7(1):1.
8
High prevalence of the prothrombin gene mutation in women with intrauterine growth retardation, abruptio placentae and second trimester loss.凝血酶原基因突变在宫内生长受限、胎盘早剥及孕中期流产女性中的高发生率。
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9
The eNOS gene: a candidate for the preeclampsia susceptibility locus?内皮型一氧化氮合酶基因：子痫前期易感基因座的候选基因？
Hypertens Pregnancy. 1999;18(1):81-93. doi: 10.3109/10641959909009613.
10
A genome-wide scan reveals a maternal susceptibility locus for pre-eclampsia on chromosome 2p13.一项全基因组扫描揭示了2号染色体p13区域上一个子痫前期的母体易感性位点。
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伊朗孕妇血管紧张素原M235T基因多态性与子痫前期的关联

Association between Angiotensinogen M235T Polymorphism and Preeclampsia in Iranian Pregnant Women.

作者信息

Afshariani Raha, Roozbeh Jamshid, Sharifian Maryam, Ghaedi Mahbobeh, Samsami Dehaghani Alamtaj, Ghaderi Abbas

机构信息

Department of Public Health, School of Health and Nutrition, Shiraz University of Medical Sciences, Shiraz, Iran.

Urology Nephrology Research Centre, Shiraz University of Medical Sciences, Shiraz, Iran.

出版信息

J Family Reprod Health. 2014 Dec;8(4):169-73.

PMID:25530769
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4266788/
Abstract

OBJECTIVE

To determine the possible association between the M235T variant of angiotensinogen gene and preeclampsia in Iranian preeclamtic women with hypertension during pregnancy.

MATERIALS AND METHODS

During a case control study, we used polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP) analysis to investigate the association between M235T polymorphism in preeclamtic women compared to normotensive controls.

RESULTS

The M235T polymorphism was significantly associated with increased preeclampsia risk in the studied population as supported by a p value of 0.017 and chi-square value of 8.12. The frequency of mutated allele and genotype distribution showed a significant difference between preeclamtic women and control groups.

CONCLUSION

The result indicates that the AGT M235T polymorphism plays a significant role in preeclampsia observed in selected Iranian preeclamtic women, and it can be considered as a major risk factor for preeclampsia.

摘要

目的

确定血管紧张素原基因M235T变异与伊朗孕期患先兆子痫并伴有高血压的女性先兆子痫之间的可能关联。

材料与方法

在一项病例对照研究中，我们采用基于聚合酶链反应的限制性片段长度多态性分析（PCR-RFLP），以研究先兆子痫女性与血压正常的对照组相比，M235T多态性之间的关联。

结果

研究人群中，M235T多态性与先兆子痫风险增加显著相关，p值为0.017，卡方值为8.12，支持了这一结果。突变等位基因频率和基因型分布在先兆子痫女性与对照组之间存在显著差异。

结论

结果表明，AGT M235T多态性在选定的伊朗先兆子痫女性中观察到的先兆子痫中起重要作用，可被视为先兆子痫的主要危险因素。