Leshchinskiĭ A F
Biull Eksp Biol Med. 1989 Jul;108(7):91-3.
It has been shown that in female rats the level of ACTH, corticosterone in the blood, relative mass of adrenals, maintenance of T3, T4 in the serum and liver was significantly higher, but the activity of liver enzyme microsomes system was lower than in males; no sex differences were observed in myocardial creatine phosphokinase system. The influence of the etimizol on the female rats significantly speed up amidopyrine N-demethylation and biotransformation of hexobarbital. In males these systems react less on etimizol, but it reduces the speed of amidopyrine N-demethylation.
研究表明，雌性大鼠血液中促肾上腺皮质激素（ACTH）、皮质酮水平、肾上腺相对质量、血清和肝脏中T3、T4的维持量显著高于雄性大鼠，但肝脏酶微粒体系统的活性低于雄性大鼠；心肌肌酸磷酸激酶系统未观察到性别差异。乙咪酯对雌性大鼠的影响显著加快了氨基比林N-去甲基化和己巴比妥的生物转化。在雄性大鼠中，这些系统对乙咪酯的反应较小，但它降低了氨基比林N-去甲基化的速度。
