Inhibition of histamine release from rat hypothalamic slices by omega-conotoxin GVIA, but not by nilvadipine, a dihydropyridine derivative.

Histamine release in response to 40 mM high K+-stimulation from the rat hypothalamic slice preparations perifused in vitro was significantly inhibited by 1.0 nM-1.0 microM omega-conotoxin GVIA, a peptide modulator of N- and L-type voltage-sensitive calcium channels, but not by similar concentrations of nilvadipine, a dihydropyridine derivative of L-type calcium channel antagonist. These results indicate that the voltage-sensitive calcium channel controlling histamine release from hypothalamic slices is omega-conotoxin-sensitive but dihydropyridine-insensitive.