微小RNA表达作为口腔鳞状细胞癌局部复发风险的预测指标

MicroRNA expression as predictor of local recurrence risk in oral squamous cell carcinoma.

作者信息

Ganci Federica, Sacconi Andrea, Manciocco Valentina, Sperduti Isabella, Battaglia Paolo, Covello Renato, Muti Paola, Strano Sabrina, Spriano Giuseppe, Fontemaggi Giulia, Blandino Giovanni

机构信息

Translational Oncogenomics Unit, Italian National Cancer Institute "Regina Elena", Rome, Italy.

Otolaryngology Department, Italian National Cancer Institute "Regina Elena", Rome, Italy.

出版信息

Head Neck. 2016 Apr;38 Suppl 1:E189-97. doi: 10.1002/hed.23969. Epub 2015 Jun 24.

DOI:10.1002/hed.23969

PMID:25532855

Abstract

BACKGROUND

Oral squamous cell carcinoma (OSCC) is the sixth most common cancer worldwide with a high rate of recurrence. MicroRNAs (miRNAs) are gene regulators playing an important role in oral carcinogenesis. The purpose of this study was for us to identify and functionally characterize miRNAs that predict recurrence in OSCC.

METHODS

We collected 92 OSCC with their normal tissue counterparts and we performed miRNAs expression profiling on 74 OSCC and 38 normal tissues. The association between the expression of miRNAs and clinical outcome was evaluated in the follow-up of 69 patients.

RESULTS

Four of the miRNAs deregulated between OSCC and normal tissues are prognostic for recurrence either when considered individually or as a group. Depletion of the expression of prognostic miRNAs inhibit the proliferation of OSCC cells

CONCLUSION

MiRNAs are differentially expressed in OSCC versus normal samples. The expression of 4 prognostic miRNA signatures is able to predict recurrence risk independently from other clinical factors in OSCC. © 2015 Wiley Periodicals, Inc. Head Neck 38: E189-E197, 2016.

摘要